Formulated by leading researchers in the fields of natural medicine and nutrition, MigreLief® is the first comprehensive supplement for the support of cerebrovascular tone.* Using a proprietary botanical plant source and nutritional supplements in the amounts shown beneficial in scientific studies, MigreLief® provides the healthcare professional with a valuable tool for patients seeking a dietary supplement to help support normal cerebrovascular tone.
* MigreLief® has been granted two U.S. Patents #6,068,999 and #6,500,450 B1.



PRODUCT DESCRIPTION

MigreLief is a unique combination of herbal and nutritional supplements aimed at supporting cerebrovascular tone, and reducing platelet aggregation and the production of pro-inflammatory mediators.*
*The herbal and nutritional ingredients in MigreLief® are used in the amounts shown to be beneficial in scientific studies.

Feverfew
Commonly recommended for its ability to support cerebrovascular tone, feverfew (Tanacetum parthenium) is rich in compounds known as sesquiterpene lactones. One of the more important of these compounds may be parthenolide, which represents 85% of the sesquiterpene lactone content in feverfew. Some scientific studies indicate that while parthenolide may be important there may very well be other phytochemicals in feverfew that are as of yet unidentified and play a role in its effectiveness. Some studies of extracts of feverfew containing parthenolide yielded no significant benefits. This lead researchers to believe that certain of the unidentified phytochemicals may have been left behind during the extraction process. The ideal solution would be a non extracted feverfew product that naturally contained high levels of parthenolide and kept all of the other naturally occurring phytochemicals as well. Thus Puracol, PR OSTEO’s proprietary non extracted plant source for feverfew with high levels of naturally occurring parthenolide was developed. Puracol, is just one of the reasons for the superior efficacy of MigreLief which delivers optimal dosages of parthenolide without being extracted. Scientific studies have found parthenolide inhibits platelet aggregation and the release of serotonin from platelets and polymorphonuclear leukocyte granules.* It has also been shown to inhibit pro-inflammatory prostaglandin synthesis and the release of arachadonic acid. Each of these phenomena are associated with migraines.* European studies have shown the benefits of feverfew on the long-term cerebrovasular tone.

*These Statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
 Magnesium is a nutritional supplement with numerous effects that support vascular tone. These include: 1) inhibition of platelet aggregation;2) interference with synthesis, release, and action of inflammatory mediators;3) direct alterations of cerebrovascular tone; 4) inhibition of vasospasm; and 5) stabilization of cell membranes.* Some persons with poor cerebrovascular tone have been found to have low brain levels of magnesium. Recommended daily dosages of magnesium typically range from 200 to 600 mg to compensate for this deficiency.

Riboflavin (vitamin B-2) is a precursor of flavin adenine dinucleotide(FAD). This coenzyme is an important component of the electron-transport chain. A deficiency of mitrochondrial energy reserves has been observed in some persons exhibiting poor cerebrovascular tone. This defect may theoretically be corrected by a compound such as riboflavin that improves the activity of the electron-transport chain.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
 

Two Caplets Provide:
 

**Protected by U.S. Patent #6,068,999 and U.S. Patent # 6,500,450 B1

*Percentage of U.S. Recommended Daily Allowance Contains no yeast, milk, corn, wheat, gluten, soy sodium, salt, sugar, flavorings, preservatives, artificial colors. This product is not intended to diagnose, treat, cure or prevent any disease.


RECOMMENDED USE

Take one caplet twice daily. MigreLief is designed to provide benefits within four to six weeks. Once results are noted, MigreLief may be used as part of a daily supplement regime and comprehensive wellness program. Each bottle contains a 4 week supply.

CONTRAINDICATIONS, ADVERSE REACTIONS OR INTERACTIONS
Side effects due to any of the ingredients in MigreLief are rare. Mild gastrointestinal upset and loose stools may occur in some persons using magnesium. This product is not recommended for use during pregnancy or lactation and should not be used in children under the age of two years. Persons taking potassium-sparing diuretics or with renal failure should not use this product.